It's kind of a blog if you don't think about it too hard
September 29, 2012
For some inexplicable reason¹, BioWare decided to not include support for the mouse wheel when scrolling through menus in Mass Effect 2. Here's an AutoHotkey script that will partially enable mouse wheel scrolling.
It works when scrolling through menu entries (Journal, Codex, etc). It does not work scrolling text boxes, such as the details that appear when you select a Codex entry. A pity, but it's better than nothing.
#IfWinActive, Mass Effect 2
SetKeyDelay, 0, 50
¹Read: Lazy PC port